Report of the DSM-V Neurocognitive Disorders Work Group

April 2009
Dilip Jeste, M.D.

  1. We have adopted the term “Neurocognitive Disorders” instead of the DSM-IV terminology of “Delirium, Dementia, and Amnestic and Other Cognitive Disorders” and the ICD-10 heading of “Organic, including Symptomatic Mental Disorders”.
  2. The disorders in this group will be those that are “acquired” - i.e. there is evidence of a decline from a previous level of neurocognitive function (based on report by a patient and/or a significant other, evidence from longitudinal data, or cross-sectional assessment of prior function).  Developmental neurocognitive disorders will be included in a separate category.
  3. Cognitive dysfunction is a feature of a number of mental disorders (e.g., schizophrenia, depression, OCD, etc.), but it is not the most prominent or the defining feature, and is not “necessary” for these diagnoses. Therefore, those conditions will not be included in Neurocognitive Disorders.
  4. The division of neurocognitive disorders into Delirium and Neurocognitive disorders, with the latter being subdivided into minor and major, was discussed. 
  5. Delirium will be considered primarily as an acute or subacute disturbance of alertness, awareness, and attention with a fluctuating course. Several issues were evaluated.  The usefulness of the term “consciousness” was discussed, given the uncertainty regarding its definition. Global disturbances of cognition and sleep-wake cycle disturbances are common associated features. An etiology-based subclassification of Delirium was also considered.  Delirium can coexist with minor or major neurocognitive disorder. 
  6. The division of Neurocognitive Disorders (other than delirium) into two subcategories based on severity of functional and/or neurocognitive impairment was discussed:    a) Minor Neurocognitive Disorder (often called Mild Cognitive Impairment or MCI), with the necessary neurocognitive impairment in only one domain, and b) Major Neurocognitive Disorder or Dementia, which would typically involve at least two domains.  However, memory impairment would not be necessary for diagnosing either of these conditions.
  7. Both Minor and Major Neurocognitive Disorders may be further subclassified according to etiology – e.g., Alzheimer disease, vascular neurocognitive disorder, Frontotemporal degeneration, Lewy Body disease, Mixed (specify which ones), Not otherwise specified (NOS). While we hope that the NOS category will be used only infrequently for the Major Neurocognitive Disorders, it may be a common category for Minor Neurocognitive Disorders in patients who seem to have Alzheimer-type picture but the clinician does not want to prematurely label the patient as having AD without longer follow-up and/or additional lab work.
  8. The criteria for non-Alzheimer dementing disorders have been and will continue to be developed independently by multiple other subspecialty groups (e.g., Lewy Body Disease group, vascular dementia groups, etc.).  Instead of reinventing the wheel, we will look at the criteria developed by these other groups, and see if we can use them, probably with some minor revisions for the sake of uniformity.
  9. The use of other specifiers to better define the clinical condition in a given patient was discussed– e.g., Course (transient, remitting, persistent but stable, persistent and worsening, persistent with fluctuations), Age of onset (<65, ≥65), Associated behavioral symptoms (e.g., agitation, wandering).

Other Issues Being Discussed

  1. Should delirium be considered along a continuum, distinguishing between subsyndromal from syndromal delirium? If so, what quantitative measure and what cut-off score should be used? Should we include subtypes of delirium such as hypo-active and hyperactive deliria?
  2. Which neurocognitive domains should be included for this purpose (e.g., memory – verbal/non-verbal, attention, working memory, language, executive functions, personality/behavior, etc.), and what tests would be optimal for assessing them? These tests may include both bedside and laboratory versions.
  3. Should the severity of impairment for diagnosing and differentiating Minor neurocognitive disorder from age-associated cognitive impairment at one end, and Minor from Major Neurocognitive Disorders at the other end, be based on neuropsychological tests and/or functional impairment? Is objective neuropsychological testing essential for a diagnosis of a minor neurocognitive disorder or can it be made solely on the basis of subjective complaints and history?
  4. How to develop and operationalize guidelines for the cut-offs to be used for minor neurocognitive disorder versus age-associated cognitive impairment, and for minor versus major neurocognitive disorder? 
  5. How to reliably measure functional impairment that might be necessary for the diagnosis of a Neurocognitive Disorder, and for differentiating Minor versus Major Disorder?  
  6. Should there a code for the level of certainty of diagnosis of a neurocognitive disorder (e.g., possible, probably, likely)?
  7. What should be the role of biomarkers such as genetics, neuroimaging, and neurochemistry in the diagnosis of these disorders?
  8. Should specific behavioral syndromes such as psychosis of AD or depression of AD be included as sub-codes under neurocognitive disorders or under psychotic disorders?

Ongoing / Planned Work

  1. Literature reviews on MCI.
  2. Assessing secondary data analysis results, including existing longitudinal data sets.
  3. Preparing draft criteria that can then lead to field tests or additional data analysis to support revision options. 
  4. Field testing of neurocognitive and functional measures.

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